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The Pioneer in Integrated Skincare Solutions Brings Advanced Anti-Aging Solutions to New Heights with Technology Inspired by the Effects of Neurotoxin Injections NEW YORK , July 23, 2024 /PRNewswire/ -- SkinCeuticals, the #1 Medical Skincare Brand, announces the brand's biggest launch to-date: P-TIOX, a new clinically backed peptide serum designed to reduce the appearance of contraction lines and reveal glass skin radiance. This innovative serum offers advanced wrinkle modulation, improved skin smoothness, and radiant skin. Inspired by the effects of neurotoxin injections and the new microtox trend, P-TIOX features a patent-pending blend of advanced peptides amplified by synergistic actives to reduce the appearance of nine types of contraction lines and reveal visibly smooth, radiant skin on all skin types and tones.

P-TIOX is physician-tested to complement neurotoxin injections and is effective on its own to achieve needle-free wrinkle correction without the aid of professional injectables. Additionally, P-TIOX is formulated with a novel blend of advanced peptides amplified by potent actives. This patent-pending combination of ingredients has shown powerful synergy compared to a peptide-based formula alone 1 : Advanced Peptide Complex with 2% Acetyl Hexapeptide-8 + 2% Dipeptide Diaminobutyroyl inspired by the effects of neurotoxin injections to help reduce the appearance of contraction lines.



Glass Skin Complex with 5% Polyhydroxy Acid + 5% Niacinamide + 1% Laminaria Extract maximizes hydration while gently exfoliating to improve texture and radiance. Results can be seen within 1 week – after 12 weeks, average results include: In 1 week: Visibly improves skin smoothness, refines the look of pores, and reveals glass skin radiance. 2 In 12 weeks: Visibly reduces 9 types of contraction lines, even those neurotoxin injections do not treat.

2 "As pioneers in integrated skincare, our goal was to deliver an innovation that pairs perfectly with the leading in-office treatment, neurotoxin injectables," states Angela Hildebrand , General Manager of SkinCeuticals U.S. "Our physician partners are thrilled.

It's great for their injectable patients and also for those who are looking for similar anti-aging benefits, but not ready for an injection treatment." "As we age, dynamic facial expressions cause contraction lines to become etched into our skin," says SkinCeuticals Partner Physician Dr. Rosalyn George .

"P-TIOX is clinically proven to reduce the look of 9 types of contraction lines, even in areas of the face that neurotoxin injections are not traditionally used to treat. Moreover, it improves skin texture and radiance in just one week of use to achieve an overall smooth, glass-like complexion – whether you're getting neurotoxin injections or not." To use, apply 4-6 drops of P-TIOX twice daily after using an antioxidant serum.

Follow with moisturizer and sunscreen in the morning. SkinCeuticals P-TIOX is available for $148 at partner skincare professionals nationwide near you (find yours at skinceuticals.com/locate) as well as at SkinCeuticals.

com. ABOUT SKINCEUTICALS SkinCeuticals ® , the #1 Medical Skincare Brand in the U.S.

and leader in antioxidant technology, founded in Dallas, TX in 1997, discovers, develops, and delivers an advanced line of scientifically backed cosmeceutical treatments. SkinCeuticals ® products have been shown to dramatically improve skin health by protecting skin from environmental damage and visibly improving skin clarity, tone, and texture to minimize the appearance of fine lines and wrinkles. SkinCeuticals® is available in over 6,000 physician offices nationwide, with over 100 of those dermatologists and plastic surgeons exclusively selling SkinCeuticals® through their flagship program and SkinCeuticals SkinLabTM destinations which specifically emphasize the SkinCeuticals integrated skincare approach — combining clinical skincare with in-office treatments.

For more information, visit the brand on Facebook, Twitter or Instagram, or at www.SkinCeuticals.com .

CONTACT Laura Cummins at SkinCeuticals: (212) 984-4907 / [email protected] 1 Protocol: Human ex vivo skin tissue was used in this study. After 2 days skin tissue culture, then skin tissues were exposed to UV irradiation (30J/cm2 UVA and 50mJ/cm2 UVB) for 4 days consecutively. After each irradiation, the fresh culture medium was replaced, then the sample was applied on the skin surface.

The positive control (VC+VE) group was administered under the liquid, and the sample group was administered on the surface. After 4 consecutive days of irradiation, the Ex vivo skin tissue was cultured for a further 3 days during which no irradiation was performed and only sample administration was performed. After treatment finished, skin samples were harvested for biomarkers analysis afterwards.

Immunofluorescence (IF) was used to detect the expression of collagen I, Collagen III, Collagen IV, Collagen XVII, Immunohisto-chemistry (IC) was used to detect the expression of elastin, Ki67, victoria blue staining was used to detect the expression of elastic fiber, masson staining was used to detect the expression of collagen fiber, the ELISA was used to detect the expression of MMP-1. 2 Protocol: A 12-week, single center clinical study was conducted on 82 females with Fitzpatrick type I-VI, (52% of subjects with sensitive skin), ages 34-65 and mild to moderate wrinkles, fine lines, pore appearance, rough skin texture evaluated by dermatologist. After cleansing, P-TIOX was applied twice daily in the morning and evening followed by a standard moisturizer and sunscreen (AM).

Subjects were asked to avoid application of any topical products to the face for at least 2 days prior to baseline. Efficacy evaluations were conducted at baseline, week 1, week 2, week 4, week 8 and week 12. SOURCE SkinCeuticals.

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