Rutgers researchers have found a new way to manage the receptors that control the sense of touch, which could lead to treating chronic pain more effectively. "Identifying a natural molecule that specifically reduces pain sensitivity offers hope for in the management of pain," said Tibor Rohacs, a professor in the Department of Pharmacology, Physiology and Neuroscience at Rutgers New Jersey Medical School and a member of the Rutgers Brain Health Institute. "Our goal is to translate these findings into effective treatments that improve the quality of life for people suffering from .
" A natural molecule called phosphatidic can reduce the activity of certain touch-sensing ion channels in the body, according to the published in . The study's first author is Matthew Gabrielle, a doctoral student in the laboratory of Tibor Rohacs at Rutgers New Jersey Medical School. Researchers found that increasing the levels of phosphatidic acid in cells makes them less sensitive to touch.
This finding was confirmed through experiments on and tests in mice, where the animals became more sensitive to touch when the formation of phosphatidic acid was inhibited. "This finding adds to a growing body of evidence suggesting that lipids are key regulators of somatosensation," said Gabrielle, referring to the body's ability to perceive sensations such as touch, temperature and pain. "By targeting the natural pathways that regulate these channels, we can develop more targeted and effective pain treatments that could be especially useful for conditions involving inflammatory pain, where current pain relief options are often inadequate.
" Matthew Gabrielle et al, Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity, (2024)..
