Dr Sandeep Mishra, a senior scientist at the Institute of Life Sciences (ILS), Bhubaneswar, on Sunday died of “heart-attack.” He is survived his wife and a little son. Dr Mishra, 56, was famous for his pioneering role in making new discoveries for effective treatment of breast cancer.
According to family members of the deceased, the scientist felt uneasy on Saturday evening following which he was rushed to the Capital Hospital. The doctors immediately administered him some injections and medicines. However, the scientist died moments later.
In 2002, the scientist had claimed that by modulating GPR141, doctors can regulate breast cancer progression and metastasis. GPRs stands for G-Protein Coupled Receptors (GPRs). The GPRs represent the largest family of cell surface receptors accounting for more than two per cent of the total genes encoded by the human genome.
Deregulated GPR signaling promotes the development, survival, and metastasis of tumor cells evident in multiple types of cancer including breast cancer. However, the molecular mechanism of the orphan molecule, GPR141, in advancing breast cancer remains elusive. “GPR141 exhibits pronounced migratory and proliferative behavior of breast cancer cells driving oncogenic pathways, validated both in vitro and in vivo.
Our findings unravel the role of GPR141 in breast cancer proliferation, metastasis, and influencing tumor microenvironment,” Dr Mishra had observed. Modulating GPR141 could pave the way for a better ther.
