A large new population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease – aortic stenosis (AS). Published today in the peer-reviewed journal Annals of Medicine , the findings are believed to be the first to highlight this previously unrecognised risk factor for the disease. It is hoped that by demonstrating this link between AS and insulin resistance – when cells fail to respond effectively to insulin and the body makes more than necessary to maintain normal glucose levels – new avenues for the prevention of the disease could open.
Aortic stenosis is a debilitating heart condition. It causes a narrowing of the aortic valve, restricting blood flow out of the heart. Over time, the valve thickens and stiffens, making the heart work harder to pump blood effectively around the body.
If not addressed, this can gradually cause damage that can lead to life-threatening complications, such as heart failure. People living with AS can take years to develop symptoms, which include chest pain, tiredness, shortness of breath and heart palpitations. Some may never experience symptoms, but may still be at risk of heart failure and death.
Previously identified risk factors for AS include age, male sex, high blood pressure, smoking and diabetes. Insulin resistance, which often develops years before the onset of type 2 diabetes, occurs when cells fail to respond effectively to insulin, the h.
_1b78fec41a5143afb6e7b9ad317023d2-620x480.jpg)
