Mayo Clinic researchers have developed an innovative testing strategy for mesothelioma that could potentially increase the detection rate of cancer DNA in the blood. This approach focuses on shuffled or swapped sections of DNA in mesothelioma cancer cells, called chromosomal rearrangements. By detecting these complex DNA patterns, rather than just single-point mutations, the method could lead to earlier diagnoses and new avenues for targeted therapies.
"We're pushing the frontiers of what's possible in blood-based monitoring," says Aaron Mansfield, M.D., a medical oncologist and lead author of the study at the Center for Individualized Medicine and the Mayo Clinic Comprehensive Cancer Center.
"Improving detection rates could offer insights into monitoring patients' responses to therapy and detecting recurrence after surgery." Mesothelioma is a rare cancer that develops in the thin membranes that line the chest and abdomen, most commonly caused by inhaling asbestos fibers . These fibers are often found in insulation, vinyl tiles, roofing materials and paint.
Despite decades of regulations to limit asbestos exposure, approximately 3,000 people in the U.S. are diagnosed with mesothelioma each year, according to the American Cancer Society.
Mesothelioma typically exhibits a low number of single-point genetic mutations , making it difficult to detect with traditional blood tests. However, the presence of chromosomal rearrangements —like shuffling words in a sentence—provides a.
