A team led by researchers at UNC-Chapel Hill have developed an innovative computer model of blood flow in the human heart that promises to transform how we understand, diagnose, and treat heart conditions. This new model, grounded in realistic mathematical descriptions of the heart's anatomy and physiology, successfully captures normal heart function and can predict how the heart responds to different levels of blood flow. The study advances the state-of-the-art in simulating heart function by incorporating three-dimensional, biomechanically detailed representations of all major cardiac structures-;derived from cardiac CT imaging and human tissue data-;to predict valve performance and model tissue biomechanics.
As a result, the team's model can more accurately evaluate heart function and responses to interventions. Importantly, it produces physiological behaviors, including pressure-volume loops and realistic responses to changing conditions, inherently from its comprehensive description of cardiac physiology. Key findings and applications The newly developed model has potential applications in various fields, including: Medical Device Design: The model can help design more effective devices by predicting changes in heart function.
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