Ketogenic diet shows promise in reducing autoimmune disease severity through microbiome and metabolic pathways. Study: A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity . Image Credit: Yulia Furman/Shtterstock.
com A recent study published in Cell Reports investigated the role of diet in host-microbiome interactions. Diet has a broad impact on autoimmune diseases, including rheumatoid arthritis, multiple sclerosis (MS), and inflammatory bowel disease. A low-carbohydrate, high-fat ketogenic diet (KD) ameliorates MS-related symptoms.
A KD is characterized by a metabolic shift to lipid oxidation, leading to higher circulatory levels of acetoacetate and β-hydroxybutyrate (βHB).KDs can shape the immune system by modulating the gut microbiota and microbiome. KD-related shifts in the gut microbiota reduce intestinal immune activation.
However, their relevance to the disease is unknown. The study and findings In the present study, researchers evaluated the role of diet in host-microbiome interactions relevant to disease. First, conventionally raised (CONV-R) mice were fed a high-fat diet (HFD) or a KD.
Ten days later, experimental autoimmune encephalitis (EAE) was induced in mice via myelin oligodendrocyte glycoprotein immunization. Disease was evaluated based on four metrics: temporal changes in disease score, maximum disease developed, overall disease incidence rate, and mice distribution across maximum disease scores. KD-fed mice had signific.
