The gut microbiota composition is distinct in patients with polycystic ovary syndrome (PCOS), relative to healthy control (HC); however, no significant difference was noted in alpha-diversity, the study finds. Study: Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data . Image Credit: NTshutterth/Shutterstock.
com A recent eClinicalMedicine study considered publicly available data to explore the characteristics of gut microbiota in PCOS patients and whether it helps distinguish different PCOS subtypes. Polycystic ovary syndrome and gut microbiota PCOS is a reproductive endocrine disorder that is characterized by polycystic ovarian morphology injury, increased androgen, hirsutism, ovulatory dysfunction, and/or acne . It poses a considerable burden on public health systems and patients.
The precise pathology and etiology of PCOS remain unclear. Additionally, available therapies are often inadequate for many patients owing to the heterogeneity of clinical phenotypes. The human gut microbiota influences the development of various diseases, such as PCOS.
Research has shown that PCOS patients have lower levels of Bacteroidota phylum and Bacteroidaceae, Porphyromonadaceae family, and higher levels of Streptococcaceae family and Bacteroidota phylum. For the treatment of PCOS, bile acid metabolism mediated by the gut microbiota is crucial. Overall, the results documented in the literature have not highlighted specific changes i.
