Metastatic cancer can be a devastating diagnosis. The cancer is spreading. It may travel to multiple organs in the body.
This could mean more pain and ultimately, death. Unfortunately, just how cancer spreads remains unclear. But now, Cold Spring Harbor Laboratory (CSHL) Professor Adam Siepel and colleagues have a way to better understand that process.
New technology developed at Weill Cornell Medicine barcodes cells to track the highways by which prostate cancer spreads throughout the body. The resulting roadmap shows that most cancer cells actually stay put within the tumor. However, it also reveals that a small number of aggressive cells seed cancer's rare migrations from the prostate to the bones, liver, lungs, and lymph nodes.
The discovery was made in collaboration with Dawid Nowak's laboratory at Weill Cornell Medicine. It involved using a new mouse model called Evolution in Cancer Prostate (EvoCaP) along with an analysis pipeline known as Evolutionary Lineage Tracing in R (EvoTraceR). This allowed scientists to use short sequences of DNA that act as genetic barcodes to trace the movement of individual cancer cells.
The new technology offers a big step up from previous methods, says Siepel. In the past, researchers might have used a combination of imaging techniques and whole-genome sequencing. But that meant more time and money.
Plus, it didn't necessarily ensure more accurate readings. This barcoding lets us read off the precise tracing information about how the canc.
