The findings underscore the need for future research on autoimmune factors in POI to improve prevention and treatment strategies. In a recent study published in Human Reproduction , researchers evaluated the relationship between autoimmune diseases and premature ovarian insufficiency (POI). Background POI is a disorder in which ovaries cease releasing eggs before the age of 40, resulting in irregular periods and menopausal symptoms.
According to studies, autoimmune disease accounts for 4-55% of all instances of POI. Females diagnosed with POI have a higher incidence of autoimmune antibodies, and thyroid antibody positivity raises the chance of developing POI. Low anti-Müllerian hormone (AMH) levels among reproductive-aged women are associated with various autoimmune diseases, including thyroid autoimmunity, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis.
About the study In the current nationwide registry-based study, researchers investigated whether POI increases the risk of autoimmune disease. The study included 3,972 females diagnosed with POI (cases) and a reference group of 15,708 age-matched females from the general population (controls). The researchers selected four controls for each POI woman.
They identified POI women from Finland’s Social Insurance Institution (SII) registry who were granted medical reimbursement for hormonal replacement treatment (HRT) due to POI before 40 years of age in the 1988-2017 period. Th.
