Zodiac killer: 11 chilling images of suspects and victims from America's most infamous unsolved serial murders Who is the Zodiac Killer? The question has plagued San Francisco area police for over 50 years and recently sparked renewed interest thanks to a Netflix documentary exploring the mystery. The killer , known as the most infamous unsolved murderer in U.S.

history, was active from 1968 to 1969. During this brief reign of terror, the killer was responsible for 37 reported crimes, with 5 confirmed kills. The murders began in 1966 when an 18-year-old college student in Riverside, California was found stabbed to death.

Two years later, another teenage couple was found shot to death near their car in a remote area north of San Francisco. In 1969, another couple was found attacked in a similar fashion, though this time, the male victim managed to survive. It was reported that shortly after the 1969 attack, an unknown man contacted police and claimed credit for the attacks in 1968.

The serial kille r struck one last time that year and killed a taxi driver by shooting him in the head. Despite being heavily investigated, police never managed to come up with a suspect. DNA clue helps 'unmask' notorious Jack the Ripper mystery in bombshell new book During the investigation, it was reported that the killer would had sent identical letters to the San Francisco Examiner, San Francisco Chronicle, and Vallejo Times-Herald reading: “Dear Editor: I am the killer of the 2 teenagers last.