Topically applied products containing human platelet extract or vitamin C provide similar improvements in age spots (photoaging) of the hands, as reported in a clinical trial within the November issue of Plastic & Reconstructive Surgery . "Our study demonstrates that two topical therapies effectively treat photoaging of the skin on the hands of middle-aged or older adults ," comments Saraya Wyles, MD, Ph.D.

, of the Mayo Clinic Department of Dermatology, Rochester, Minn. "With both types of over-the-counter products, the outcomes appear similar or superior to those of more invasive treatments." Direct comparison of HPE versus vitamin C for photoaging of the hands Brown spots on the hands, sometimes referred to as age spots or liver spots, are a common cosmetic issue caused by sun damage to the skin.

Treatments for skin rejuvenation and resurfacing—such as chemical peels, injectables, and intense pulsed light or laser treatments—have primarily focused on the face, with less attention to the hands and other visible parts of the body. In recent years, products with human platelet extract containing–platelet exosomes (HPE) have drawn "tremendous attention" as topical treatments for photoaging skin. Safely derived from specially processed human platelets, HPE products have shown improvements in overall skin appearance.

Topical products containing vitamin C and other antioxidants have also been shown to effectively reduce signs of facial aging. Dr. Wyles and colleagues designe.