The Substance , the Cannes Film Festival winning, Demi Moore body swap horror movie, is poised to bust to great heights at the global box office with a $70M-$75M take. That’s quite a landmark for the Working Title produced-2 hour and 21-minute running, French shot movie which has the Ghost and $2.5 billion global grossing blockbuster actress in the awards season conversation for her portrayal of an aerobics instructor TV star, Elizabeth, who soon realizes her days are over in Hollywood.

However, she gets the opportunity to participate in a body swap experiment which introduces the world, and her former TV audience, to much younger version of herself, under the new alias Sue (Margaret Qualley). Consequences, as unsexy as they are, ensue. The movie received a 13-minute standing ovation at its Cannes premiere back in May and won Best Screenplay for its filmmaker Coralie Fargeat .

Moore has been public about the challenges during filming: Battling Shingles and losing 20 pounds. The Substance repped streamer MUBI ‘s first big wide theatrical release splash, opening on Sept. 20 stateside with $3.

2M in 6th place at 1,949 theaters. Lionsgate dated on top of the genre movie with their own, the Halle Berry horror film, Never Let Go, which out notched Substance on the chart with a $4.4M start off a TV spot campaign vs.

MUBI’s digital and social push. Despite being a few steps behind, the fitness guru horror has shown the greater stamina at the B.O.

, besting Berry stateside, $16.2M.