Air cargo remains crucial to the global supply chain, moving everything from electronics and pharmaceuticals to perishable goods and urgent supplies. The largest air cargo operators play an essential role in this ecosystem, employing vast fleets of dedicated freighters and leveraging global networks to connect key trade hubs. Below, we examine five of the most prominent players in the air cargo industry, detailing the scale, fleet, and operational reach that set them apart.

1 FedEx Express Fleet size and global reach FedEx Express, the air cargo subsidiary of FedEx , commands one of the largest dedicated freighter fleets worldwide. With over 700 aircraft in its fleet, FedEx serves more than 220 countries and territories, establishing it as a leader in global express delivery. From the Boeing 777F, known for its long-haul capabilities, to the Cessna 208 Caravan for regional hops, FedEx's diverse fleet can handle various routes and cargo sizes.

Key hubs and operational efficiency FedEx operates multiple significant hubs, with its most prominent in Memphis, Tennessee, where it handles an average of 3.3 million packages daily. Other primary hubs include Paris-Charles de Gaulle and Guangzhou, connecting critical trade corridors across North America, Europe, and Asia.

The carrier's extensive route network and efficient logistics enable FedEx to offer reliable overnight and two-day shipping options globally. FedEx founder Smith turned a Yale idea into a global logistics powerhouse, .