Prof. Heiko Lickert is the director of the Institute of Diabetes and Regeneration Research at Helmholtz Munich, professor at the Technical University of Munich (TUM), and member of the German Center for Diabetes Research (DZD). Together with his team, they discovered Inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway.
Both Inceptor and the insulin receptor are located on the surface of beta cells, where Inceptor can block the insulin receptor, thus reducing the cells' insulin sensitivity and weakening the signaling pathway. The current study goes further, showing that Inceptor binds excess insulin within the beta cell and directs it towards degradation. "This knowledge about Inceptor's function gives us a deeper understanding of how beta cells regulate their insulin homeostasis," says Heiko Lickert.
Regeneration of damaged beta cells The increased presence of Inceptor in beta cells suggests that the receptor plays a role in insulin secretion, which is regulated by beta cells. This process is often impaired in diabetes, leading to elevated blood sugar levels. By blocking Inceptor, the researchers were able to refill beta cells' insulin stores, enhance insulin release, and prevent beta cell death.
Especially in already damaged cells, blocking Inceptor could help boost insulin production and protect the beta cells." Heiko Lickert, Director, Institute of Diabetes and Regeneration Research, Helmholtz Munich Hope for people with type 2 diabetes.