Physician-scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine have new insights into the role of genetic risk scores in guiding treatment for hypertension, or high blood pressure. The study , published in Mayo Clinic Proceedings , examines the application of the systolic blood pressure polygenic risk score in guiding the personalization of treatment strategies for patients with elevated blood pressure or stage 1 hypertension.
Hypertension remains a leading cause of cardiovascular disease. Genetic predispositions account for a significant portion of blood pressure variability. This study investigates how genetic risk scores can enhance a patient's risk assessment and tailor treatments.
The research, led by Naman Shetty, M.D., and colleagues, analyzed data from more than 5,000 participants.
The genetic predisposition to hypertension was quantified using a previously validated systolic blood pressure polygenic risk score . The findings revealed that the SBP PRS was instrumental in classifying patients' risks of adverse cardiovascular events, such as coronary heart disease , heart failure and stroke. Prior research led by Pankaj Arora, M.
D., the senior author of the current work and physician-scientist at the UAB Cardiovascular Institute, demonstrated that coronary artery calcium scores were instrumental in guiding the initiation of antihypertensive therapy. Based on prior work with CAC scores, Arora and his team examined whether using bo.