Investigators analyzing the potential cognitive effects of antidiabetic medications in records of more than 1.5 million patients with type 2 diabetes mellitus (T2DM) found risks of dementia and Alzheimer's disease (AD) were significantly lower in patients treated with metformin and sodium glucose co-transporter-2 inhibitors (SGLT-2i) compared to other antidiabetic drugs. Their results appear in the American Journal of Preventive Medicine , published by Elsevier.
T2DM has become a critical health issue, affecting around 530 million patients worldwide. Growing evidence demonstrates there is at least a 50% increased risk of cognitive impairment and dementia in patients with T2DM, manifested as impaired executive function, memory, and attention. Dementia itself is also a crucial health issue, affecting more than 40 million patients worldwide.
Lead investigator Yeo Jin Choi, PharmD, PhD, Department of Pharmacy, College of Pharmacy; Department of Regulatory Science, Graduate School; and Institute of Regulatory Innovation Through Science (IRIS), Kyung Hee University, Seoul, Korea, explains, "As the prevalence of both diabetes and dementia continues to rise each year, and with mounting evidence suggesting a strong correlation between diabetes and dementia, the need for comprehensive research in dementia risk associated with antidiabetic treatment becomes increasingly imperative. Understanding the potential cognitive effects of antidiabetic medications is not only crucial for optimizi.