Teens who faced high levels of emotional and multidimensional adversity in their early years are at the most significant risk for mental health challenges, a comprehensive 15-year study revealed. These teens also exhibit significant differences in brain activity related to emotion processing, according to the University of Michigan research published in JAMA Network Open. The study tracked over 4,000 youths from birth to age 15, examining how a range of childhood adversities—such as maltreatment, family violence and maternal depression—affect later mental health and brain function.

The findings showed that youth exposed to high levels of adversity in multiple contexts (home, family, neighborhood) suffered worse mental health outcomes and altered brain function. Notably, maternal depression alone could produce similar negative effects, even when other adversities were only moderate. Using a clustering method, researchers identified four profiles of childhood adversity: Low adversity: Minimal exposure to adverse experiences Medium adversity: Moderate levels across various domains Maternal depression: Moderate adversity with high levels of maternal depression High adversity: Significant adversity across all measured domains Adverse childhood experiences occurring within and outside the home are considered pervasive risk factors for poor health.

” Christopher Monk, professor of psychology and psychiatry and research professor at the U-M Institute of Social Research “Howeve.