A recent Nutrients study evaluates the neuroprotective properties of Ecklonia cava polyphenols (ECPs) in alleviating neuronal damage caused by rotenone in Parkinson’s disease (PD). Study: Ecklonia cava Polyphenols Have a Preventive Effect on Parkinson’s Disease through the Activation of the Nrf2-ARE Pathway. Image Credit: C Levers / Shutterstock.
com PD and rotenone PD is a common neurodegenerative disorder that manifests as motor symptoms, including rigidity, tremor, and motor laxity, as well as non-motor symptoms, such as depression and cognitive impairment. Previous studies have shown that the risk of PD onset increases three-fold every decade after the age of 60. Due to the rapid aging of the global population, PD cases are estimated to reach 14.
2 million by 2040. To date, scientists have failed to develop any treatment to attenuate the progression of PD. The underlying mechanisms associated with PD pathogenesis include dopaminergic neuronal death, mitochondrial dysfunction, oxidative stress, intracellular reactive oxygen species (ROS) generation, neuroinflammation, and the abnormal accumulation of α-synuclein protein.
PD can be further classified as autosomal dominant/recessive or sporadic. Approximately 10-15% of PD cases are genetically linked, whereas the remaining cases are considered sporadic and may arise due to various risk factors. For example, environmental factors, such as exposure to neurotoxic substances like pesticides, increase the risk of developing sp.