With the aging of the global population, the prevalence of metabolic diseases has significantly increased over the past two decades. Meanwhile, China grapples with the largest population aged 65 years and older and a faster pace of population aging than many other countries. This demographic shift contributes to the escalating burden of age-related chronic diseases.
Accumulating evidence also suggests gender disparities in the prevalence and incidence of chronic diseases, and while numerous studies have been conducted on this topic, many overlook the crucial covariate of age. Recognizing the interplay between sex and age is crucial for understanding the trajectories of cardiometabolic diseases and its upstream risk factors, as well as for promoting individualized intervention strategies. Previous studies in the global or European population investigated the age-related sex differences in a range of risk factors, but there is a paucity of gender-specific analyses pertaining to the trajectories of risk factors for adults in China.
Recently, Dr. Weiqing Wang at Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine a paper in entitled "Exploring age and in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study." Based on the Risk Evaluation of cancers in Chinese diabetic Individuals: a longitudinal (REACTION) study, a total of 254,670 adults aged 40−80 years were included in this study, who were recruited f.