A newly discovered code within DNA—coined "spatial grammar"—holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding, identified by researchers at Washington State University and the University of California, San Diego and in , revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists' understanding of and how genetic variations may influence in development or disease.
Transcription factors, the proteins that control which genes in one's genome are turned on or off, play a crucial role in this code. Long thought of as either or repressors of gene activity, this research shows the function of transcription factors is far more complex. "Contrary to what you will find in textbooks, transcription factors that act as true activators or repressors are surprisingly rare," said WSU assistant professor Sascha Duttke, who led much of the research at WSU's School of Molecular Biosciences in the College of Veterinary Medicine.
Rather, the scientists found that most activators can also function as repressors. "If you remove an activator, your hypothesis is you lose activation," said Bayley McDonald, a WSU graduate student who was part of the research team. "But that was true in only 50% to 60% of the cases, so we knew something was off.
" Looking closer, researchers found the function of many transcription factors was highly position dependent. They discovered that the spacing between transcr.