Researchers from Tianjin University have created an innovative injectable hydrogel that regulates immune cell metabolism, offering a promising new treatment for rheumatoid arthritis. Beijing: A research team from north China's Tianjin University has developed a new type of injectable hydrogel that can regulate immune cell metabolism, helping to reduce inflammation and slow down rheumatoid arthritis. Rheumatoid arthritis is a painful and relentless chronic disease.
It occurs when the body's immune system mistakenly attacks healthy joints, leading to deformities and disabilities, making everyday life a struggle for millions of people, Xinhua news agency reported. Scientists have discovered that a key factor in this process is the metabolism of immune cells, particularly macrophages. When these cells' metabolic pathways go off balance, they release excessive inflammatory signals that worsen the disease.
If this metabolism could be controlled, it might open up a new way to treat rheumatoid arthritis. The novel hydrogel developed by the researchers is made from biodegradable alginate and has a special dual-network structure, making it easy to inject and allowing for the controlled release of therapeutic agents. Once inside the joint, the hydrogel reacts to the acidic environment of the inflamed area, gradually releasing zinc ions and small interfering RNA.
These substances help reprogram the macrophages' metabolism, reducing their ability to trigger inflammation and enhancing thei.