Analysis features the growing need to evolve anticoagulation therapy beyond warfarin to avoid gastrointestinal bleeding, a significant and common complication for left ventricular assist device (LVAD) patients resulting in expensive hospitalizations Tecarfarin, a novel vitamin K antagonist (VKA), uses a different metabolic pathway than warfarin, the most commonly used anticoagulant for LVAD patients, and may offer more stable and effective anticoagulation PONTE VEDRA, Fla. , Aug. 20, 2024 /PRNewswire/ -- Cadrenal Therapeutics, Inc.
, (Nasdaq: CVKD ), a biopharmaceutical company developing tecarfarin, a late-stage, next-generation VKA oral and reversible anticoagulant (blood thinner) designed to prevent heart attacks, strokes, and deaths due to blood clots in patients with implanted cardiac devices or rare cardiovascular conditions, today highlighted a manuscript that was recently peer-reviewed and published in the Journal of Cardiac Failure evaluating the relationship between time in therapeutic range, or TTR, management quality and LVAD patient clinical outcomes. These findings focus on the potential role of investigating new VKA agents beyond warfarin in improving clinical outcomes in LVAD patients. In the manuscript co-authored by Mandeep R.
Mehra , MD, MSc, FRCP, Brigham and Women's Hospital Heart and Vascular Center, Center for Advanced Heart Disease, titled " Antithrombotic Strategies with Left Ventricular Devices ," the findings conclude that although the current gener.