New study reveals that specialized ribosomes, driven by cytokine signals, help tumors evade the immune system, offering a breakthrough pathway for enhancing cancer immunotherapies. Study: P-stalk ribosomes act as master regulators of cytokine-mediated processes . Image Credit: ALIOUI MA / Shutterstock In a recent study published in the journal Cell , researchers conducted extensive translational experiments on both in vivo murine model systems and in vitro human melanoma cell lines to enhance our understanding of the processes involved in cytokine-induced cellular rewiring, especially following ribosomal changes.
PSR Role in T-Cell Recognition: The study reveals that P-stalk ribosome (PSR) knockdown dramatically reduces CD8+ T cell recognition of tumor antigens , underscoring the central role of PSRs in enabling immune detection of tumors. Study findings reveal that P-stalk ribosomes (PSRs) are essential mediators of cellular signal convergence, influencing pro- and anti-inflammatory cytokine regulation. These processes progress via previously unverified translation mechanisms, particularly phosphorylation.
PSRs specifically drive the translation of mRNAs critical for cytokine responses, including those involved in antigen presentation and immune surveillance. Notably, this mechanistic interaction was found to be cell- and cancer-type agnostic, providing a generalized mechanism of tumor immune evasion. These findings are, hence, invaluable in helping prevent or treat multiple.