Postural: your body’s posture or position Orthostatic: drop in blood pressure upon standing after sitting or lying down Tachycardia: rapid heart rate Syndrome: a collection of symptoms Neuropathic: Neuropathic POTS is associated with damage to the small fiber nerves, which regulate blood vessel constriction in the limbs and abdomen, leading to blood pooling in the lower extremities. According to one 2007 study , about 50 percent of POTS patients show signs of nerve damage affecting sweating. These nerve problems cause blood to pool in the legs, often causing a bluish color in the skin.
Partial dysautonomic: Partial dysautonomic POTS involves mild damage to nerves that control involuntary bodily functions (peripheral autonomic neuropathy), particularly affecting the heart rate and peripheral blood vessels. This damage makes it difficult for the body to regulate blood pressure effectively, especially when standing, leading to blood pooling in the lower body. Hyperadrenergic: Hyperadrenergic POTS is characterized by elevated levels of the stress hormone norepinephrine and overactivity of the sympathetic nervous system, which is responsible for the body’s response to threatening situations.
Approximately 30 percent to 60 percent of POTS patients have this subtype. In some cases, a genetic mutation in the norepinephrine transporter (SLC6A2) can lead to deficient norepinephrine transport, causing rapid heartbeats, palpitations, tremors, high blood pressure, and anxiety. Certain.