Overusage of paracetamol: How much is too much?

Listen to Story Paracetamol has been a rescue pill for most Indians. Almost every household has a strip of this medicine as it is a common over-the-counter painkiller used to treat headaches, muscle aches, and even fever. But most people often end up popping a paracetamol for the slightest symptom, which should be taken as caution.

Despite its widespread use and perceived safety, paracetamol also called acetaminophen , carries significant risks, particularly to the liver, when not used according to recommended guidelines. Paracetamol works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for inflammation and pain. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or aspirin , paracetamol does not have significant anti-inflammatory properties, making it a more suitable option for those who need pain relief without the risk of stomach irritation.

While paracetamol is a safe drug, consuming more than the recommended dose could lead to liver damage. The liver is responsible for metabolising paracetamol, breaking it down into various substances, some of which are toxic. Under normal circumstances, the liver can handle these toxins by converting them into harmless substances that are then excreted from the body.

However, when paracetamol is taken in excessive amounts, the liver's ability to process these toxins is overwhelmed, leading to liver damage. According to the National Library of Medicine, liver toxicity from p.