Ovarian cancer is one of the most common malignancies in women worldwide. Unlike breast cancer, ovarian cancer lacks early diagnostic markers and does not show noticeable symptoms until cancer metastases, leading to a low survival rate for ovarian cancer patients. Traditional cancer treatments include surgery, radiation therapy, chemotherapy and interventional therapy.
However, the distribution of chemotherapeutic drugs in vivo is non-specific and often toxic to healthy cells, leading to unsatisfactory efficacy . In a study published in the KeAi journal Biomedical Analysis , a group of researchers from China outline a new discrimination and treatment approach -; a novel exosome-based drug delivery system that could improve the cell entry ability of drugs and the targeting of cancer cells. This approach provides a new drug delivery system and synergistic therapy idea, paving the way for future clinical applications.
Exosomes are extracellular vesicles with lipid bilayers that have been extensively used as delivery vehicles for multiple drugs due to their high biocompatibility, low immunogenicity, the abilities to cross various biological barriers and evade the clearance by immune system. The synergistic cancer treatment by loading various nucleic acids and drugs into exosomes utilizes the advantages of different therapeutic approaches and has been applied to effectively treat cancers through the synergy of different treatment mechanisms." Songqin Liu, study's corresponding aut.