When it comes to key ingredients, Missouri can't be certain lately when a vital piece in its recipe for winning is available. And it turns out Tigers star quarterback Brady Cook won't be on the field Saturday when No. 24 Missouri plays Oklahoma on Saturday in Columbia, Mo.

Cook was ruled out Friday due to ankle and wrist injuries. He missed parts of the past two games due to the ailments -- first the ankle injury and then the wrist injury. Coming off a bye week, head coach Eli Drinkwitz was hopeful Cook could return as he was ahead of where he was in terms of health prior to the 34-0 loss to Alabama on Oct.

26. He played in that game, though, and sustained the wrist injury after completing 7 of 12 passes. The missed contest will end Cook's streak of 35 consecutive starts.

He ranks fourth in school history with 8,053 career passing yards and sits fifth with 45 touchdown passes. With Cook, the Tigers offense has been dynamic. "He's got great juice and just, he's fearless," Oklahoma coach Brent Venables said of Cook.

"I don't know his entire background, but he's a winner. I think he brings out the best in the players around him. .

.. You can see the guts and the toughness.

" With Cook out, Drew Pyne will start for Missouri (6-2, 2-2 SEC). Pyne came on in relief of Cook against both Auburn and Alabama, throwing three interceptions in the loss to the Crimson Tide. "We put him in some bad situations," Drinkwitz said of Pyne.

"We've got to protect better. We've got to establish the ru.