The Los Angeles Chargers were handed their first defeat in crushing fashion last Sunday against the Pittsburgh Steelers, a loss that also saw the team suffer a handful of injuries to top players. As a result, Justin Herbert, Joe Alt, Rashawn Slater and Joey Bosa could be out of action this week when the Chargers face the undefeated Kansas City Chiefs, who happen to be the team that stands in their way of winning the division and likely, advancing in the playoffs, this season. This was a game that many NFL fans circled on their calendars when the schedule was released.

Jim Harbaugh vs. Andy Reid. Could the Chargers send a strong message early in the season that the AFC West isn't going to be the cakewalk that it has been? Chargers OTs Rashawn Slater (pectoral), Joe Alt (MCL sprain) expected to miss Week 4 vs.

Chiefs, per @RapSheet https://t.co/jlcqEk5W0O pic.twitter.

com/kV0xGdMCQS Without those key injuries, that would have been a serious question. Now, it's a lot more questionable, as will be the game statuses for those players. What do the experts think? NFL picks, predictions Week 4: Chargers vs.

Chiefs Vinnie Iyer, The Sporting News: Chiefs 23, Chargers 17 Iyer: "This should be a marquee game with Patrick Mahomes vs. Justin Herbert as the undercard to Andy Reid vs. Jim Harbaugh.

However, Herbert aggravated his foot injury during the loss to Pittsburgh, and the Chargers could be stuck with a run-heavy game plan and a backup QB. Harbaugh, however, will find a way to grind wi.