In a recent study published in Nature Communications , researchers from the United States of America investigated the association between platelet hyperreactivity and the risk of cardiovascular events. They developed the platelet reactivity expression score (PRESS) to identify individuals with hyperreactive platelets. They found that patients with peripheral artery disease (PAD) and hyperreactive platelets had a higher incidence of cardiovascular events, and PRESS could effectively identify individuals with hyperreactive platelets and higher cardiovascular risk.
Study: A Platelet Reactivity ExpreSsion Score derived from patients with peripheral artery disease predicts cardiovascular risk . Image Credit: Jo Panuwat D/Shutterstock.com Background Platelets are crucial in atherogenesis and thrombosis, and increased platelet activity is linked to higher long-term mortality and cardiovascular events.
Despite advancements in our understanding of platelet biology through transcriptome analyses, routine clinical assessment of platelet aggregation remains challenging. The Platelet Activity and Cardiovascular Events in PAD (PACE-PAD) study aimed to explore the association between platelet activity and major adverse cardiac or limb events (MACLE) in symptomatic PAD patients undergoing lower extremity revascularization. It also sought to identify a platelet hyperreactivity signature using platelet transcriptomics.
In the present study, researchers developed a score named “PRESS” with .