A new study brings researchers closer to better understanding the pathology of the fatty liver disease MASH, which stands for metabolic dysfunction-associated steatohepatitis. MASH is a consequence of poor diet and obesity and results in severe damage to the liver. In MASH, the liver becomes filled with active and rapidly multiplying T cells , which are a type of immune cell.
In today's study, published in Hepatology , researchers examine what these T cells look like and how they work in people with liver cirrhosis (a late stage of liver disease) and in an animal model of MASH. Our goal is to provide a more thorough understanding of the mechanisms that drive MASH. A better understanding can lead to people being diagnosed earlier or before the disease is at such a late stage that a liver transplant may be the only treatment option.
" Matthew Burchill, PhD, paper's senior author, associate professor of medicine at the University of Colorado Anschutz Medical Campus MASH is a slow killer in that the progression of the disease takes place over the course of decades. Despite this, MASH is rapidly becoming the most prevalent liver disease worldwide. It's estimated that approximately 40 percent of the adult population in the United States is obese, and approximately 14 percent of asymptomatic middle-aged individuals in the US have biopsy proven MASH, according to a recent study in the Journal of Hepatology.
Burchill and his team found during MASH, T cells multiply and change in functi.