Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) and the German Center for Diabetes Research (DZD) have published a in that sheds light on the molecular adaptations occurring in skeletal muscle following bariatric surgery, particularly in individuals with and without type 2 diabetes. Bariatric surgery is a widely recognized intervention for obesity management. The medical intervention alters the digestive system to limit the amount of food that can be eaten or absorbed or affect hunger via the incretin system, thereby promoting significant and sustained weight loss.
Bariatric surgery is typically considered for individuals who have not achieved long-term weight loss through diet and exercise. It is known that during the development of type 2 diabetes (T2D), (DNA methylation and hydroxymethylation) occur in , a key tissue taking up glucose in response to insulin. However, it is unclear to what extent these alterations are reversible through interventions such as .
Linking clinical outcomes to transcriptome and epigenome Therefore, an interdisciplinary DZD team including the researchers Leona Kovac, Annette Schürmann and Meriem Ouni from the DIfE as well as Sabine Kahl and Michael Roden from the German Diabetes Center (DDZ) investigated the effects of surgically induced weight loss on metabolic, transcriptional, and epigenetic adaptations in skeletal muscle of obese individuals with and without T2D by using a comprehensive bioinformatic appro.