Researchers from the University of Cincinnati College of Medicine and Cincinnati Children's Hospital have found a new method to increase both speed and success rates in drug discovery. The study, published Aug. 30 in the journal Science Advances , offers renewed promise when it comes to discovering new drugs.
"The hope is we can speed up the timeline of drug discovery from years to months," said Alex Thorman, PhD, co-first author and a postdoctoral fellow in the Department of Environmental and Public Health Sciences in the College of Medicine. Researchers combined two approaches for screening potential new drugs. First, they used a database from the Library of Integrated Network-based Cellular Signatures (LINCS) to screen tens of thousands of small molecules with potential therapeutic effects simultaneously.
Then they combined the search with targeted docking simulations used to model the interaction between small molecules and their protein targets to find compounds of interest. That sped up the timing of the work from months to minutes -; taking weeks of work required for initial screening down to an afternoon. Thorman said this faster screening method for compounds that could become drugs accelerates the drug research process.
But it's not only speed that is crucial. He added that this newer approach is more efficient at identifying potentially effective compounds. "And the accuracy will only improve, hopefully offering new hope to many people who have diseases with no kno.