Innovative diagnostic kit uses fluorescence-based detection to achieve 90% accuracy in identifying early-stage bladder cancer. Study: Diagnosis of early-stage bladder cancer via unprocessed urine samples at the point of care . Image Credit: Orawan Pattarawimonchai/Shutterstock.
com In a recent study published in Nature Biomedical Engineering , a research team from the Republic of Korea explored a novel diagnostic system for detecting early-stage bladder cancer using unprocessed urine samples. The study showed that the device uses a two-layer system and floating particles to send fluorescent signals, removing the need for sample preparation and making it a promising option for early detection of bladder cancer at home. Background Bladder cancer is one of the most globally prevalent forms of cancer and is characterized by high recurrence and progression rates.
Early diagnosis, particularly during non-muscle-invasive stages, is crucial as it significantly improves survival outcomes. However, current diagnostic methods, such as cystoscopy and urine cytology, are invasive, costly, and require specialized personnel. Moreover, these approaches often lack sensitivity for early detection and are often affected by the heterogeneity of urine samples.
Several non-invasive, urine-based diagnostic methods, including molecular and enzymatic assays, have emerged in recent times. However, these methods frequently require sample pre-treatment or fail to maintain accuracy in detecting biomarkers.