Scientists are focusing on the energy centers of cancer cells – in a literal sense – to damage these power sources and induce widespread death in cancer cells. In a recent study, researchers combined methods to administer gene therapy that disrupts energy using nanoparticles designed to specifically target only cancer cells. Tests indicated that the targeted treatment is successful at reducing glioblastoma brain tumors and aggressive breast cancer tumors in mice.
The research team addressed a major hurdle by utilizing a cutting-edge technique to dismantle mitochondria – the energy centers of the cell – through a method that creates light-activated electrical currents within the cell. They named this innovative technology mLumiOpto. “We disrupt the membrane so mitochondria cannot work functionally to produce energy or work as a signaling hub.
This causes programmed cell death followed by DNA damage – our investigations showed these two mechanisms are involved and kill the cancer cells,” said co-lead author Lufang Zhou, professor of biomedical engineering and surgery at The Ohio State University . “This is how the technology works by design.” Mitochondria play a crucial role as the powerhouses of cells, generating the energy necessary for cellular functions.
For years, they have been seen as a promising target for anti-cancer therapies, yet their impermeable inner membrane has posed significant challenges. Five years ago, Zhou’s lab discovered a way to take .