In his doctoral dissertation completed at the University of Jyväskylä, Finland, Tero Sievänen demonstrates that the cancer risk of Lynch syndrome carriers can be assessed based on circulating microRNA profiles. This helps in developing current screening methods and targeting screenings for high-risk individuals. Additionally, the study corroborates previous findings by demonstrating that a healthy lifestyle can mitigate cancer risk in Lynch syndrome carriers.
Lifestyle factors, such as weight gain, and their association with cancer development were found to be particularly pronounced in men Lynch syndrome is a hereditary cancer syndrome that predisposes its carriers to various cancers, especially colorectal cancers. Due to the hereditary cancer risk, Lynch syndrome carriers undergo cancer screenings throughout their lives. However, current research indicates the need to improve the current screening methods to better account for individual cancer risk and more effectively target high-risk carriers.
It has been shown that circulating microRNA profiles can be used in predicting non-hereditary colorectal cancer development. MicroRNAs are small molecules that regulate gene expression in their target tissues, in response to factors such as diseases and physical activity. Circulating microRNAs are also an important part of intercellular communication, which is why their levels can reflect changes occurring in tissues.
The aim of this study was to assess whether circulating mi.