MATTHEW Perry's tragic final words to his assistant before his fatal ketamine overdose have now been revealed. Perry was found unresponsive in the hot tub of his LA home on October 28 last year, having suffered acute effects of ketamine and drowning, his autopsy revealed. The Friend's star, 54, asked his live-in assistant Kenneth Iwamasa to "shoot him up with a big one", suggesting he had already been on a ketamine dose before, according to court documents obtained by NBC news.

It is understood this was his final dose shortly before he was found dead. The court documents revealed Perry on October 28 had asked his assistant to administer his first shot of the day around 8.30 in the morning.

He was given another dose of the drug - again by Iwamasa - about four hours later, while he was watching a movie inside his lavish LA mansion, PageSix reports. The star had then asked his assistant to "prepare his jacuzzi" before asking him to give the third shot of the day. After administering the dose, understood to Perry's final, Iswama left his boss at the mansion to go out and run errands, only to find him dead upon returning.

It comes as five people, including Iwamasa, were charged for the fatal drug overdose of the famed star on Thursday. Other suspects named in the federal indictment were Perry's doctors Salvador Plasencia and Mark Chavez, broker Mark Fleming, and accused drug dealer Jasveen Sangha. Iswama said in a plea deal he had been administering ketamine to Perry for about a m.