Authorities are releasing more details into Matthew Perry 's final days after five people were charged in connection to his death . The Friends alum was found dead in the hot tub of his Los Angeles home on Oct. 28, with his cause of death later determined to be "acute effects of ketamine" in drug and drowning-related accident .
However, it wasn’t the first time he experienced negative effects of the dissociative anesthetic. Perry had an "adverse medical reaction" to an at-home ketamine injection on Oct. 12, just 16 days before his death, prosecutors said in unsealed Department of Justice documents reviewed by E! News Aug.
16. Prosecutors alleged defendant Dr. Salvador Plasencia injected the 54-year-old with "a large dose" of the controlled substance at request of the Perry's live-in assistant Kenneth Iwamasa , who has also been charged in the case, after the actor had already undergone ketamine infusion therapy from a doctor's office .
The DOJ said the at-home ketamine caused a "significant spike" to Perry's systolic blood pressure, making him "freeze up" so much that he "could not speak or move." Prosecutors alleged that Plasencia told Iwamasa "something to the effect of: 'let’s not do that again'" following Perry's reaction to the additional dosage, though the assistant continued to purchase ketamine for at-home use in the following days. Iwamasa has pleaded guilty to one count of conspiracy to distribute ketamine causing death, per authorities.
Meanwhile, Plasencia is .