University of Montreal and McGill University researchers in Canada have identified a significant association between hidradenitis suppurativa (HS) and higher risks of adverse pregnancy outcomes, as well as long-term health issues for both mothers and their children. Hidradenitis suppurativa is a chronic inflammatory skin disorder characterized by painful, recurring, rounded nodules and abscesses in areas of the body with sweat glands . HS is linked to elevated levels of pro-inflammatory cytokines.
These cytokines may increase the risk of pregnancy complications such as preeclampsia, gestational diabetes , and preterm birth . Additionally, HS is associated with autoimmune and endocrinologic comorbidities that can further impact pregnancy outcomes. In the longitudinal retrospective cohort study, " Hidradenitis Suppurativa and Maternal and Offspring Outcomes ," published in JAMA Dermatology , researchers analyzed over 1.
3 million deliveries, identifying 1,332 pregnancies among mothers with HS. Findings indicate that mothers with HS face a 55% higher risk of hypertensive disorders related to pregnancy, a 61% increased risk of gestational diabetes, and a 38% greater risk of severe maternal morbidity compared to those without HS. Babies born to mothers with HS experienced a 28% higher risk of preterm birth and a 29% increased likelihood of birth defects.
Long-term analysis revealed that mothers with HS had more than double the risk of hospitalization, while their children had a 31%.