Impact of oxidative stress, gut, and diet on attention deficit hyperactivity disorder pathophysiology

Oxidative stress and gut-brain axis identified as key contributors to ADHD development, highlighting potential dietary interventions. Study: Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder . Image Credit: PeopleImages.

com - Yuri A/Shutterstock.com In a recent review published in Nutrients , researchers investigated the influence of oxidative stress (OS) in attention deficit hyperactivity disorder (ADHD) development. Introduction ADHD is a childhood neurodevelopmental disease marked by difficulty paying attention, impulsive behavior, and hyperactivity.

The disease is associated with various mental problems, addictions, accidents, and comorbidities such as anxiety and depression. Heredity plays a vital role in ADHD development. Non-genetic factors such as oxidative stress also contribute to ADHD symptoms.

Gut microbes regulate oxidative stress and systemic inflammation, influencing mental health. Diet can influence microbiota, hence altering brain function and cognitive symptoms. About the review In the present systematic review, researchers determined whether oxidative stress (OS) contributes to attention deficit hyperactivity disorder (ADHD) development.

They also explored the mediating effects of the gut-brain axis (GBA) and diet on ADHD. The researchers searched PubMed, Google Scholar, and ScienceDirect databases for studies determining associations between oxidative stress, GBA, diet, and ADHD, published in English unt.