New clinical research shows that glutathione can effectively reduce acetaldehyde levels in the bloodstream, offering a promising solution for hangover relief. Image Credit: ShotPrime Studio / Shutterstock In a recent study published in the journal Nutrients , researchers in the Republic of Korea evaluated the effects of glutathione (GSH) on alcohol metabolism and hangover relief by reducing serum acetaldehyde levels. Background Alcohol consumption is widespread globally, but the resulting hangovers can lead to discomfort, such as headaches, dizziness, and fatigue, significantly impacting daily activities like work performance and driving.
Managing hangovers is crucial due to its medical, social, and economic impact. Alcohol is primarily metabolized in the liver, where it is converted to acetaldehyde, a toxic compound. Significantly, acetaldehyde plays a central role in causing hangover symptoms.
Excessive alcohol use activates cytochrome P450 2E1 (CYP2E1), producing harmful reactive oxygen species (ROS) and reducing glutathione, a vital antioxidant. GSH (glutathione-rich yeast extract) helps detoxify acetaldehyde, potentially relieving hangover symptoms. Further research is needed to better understand the long-term effects, optimal dosage, and mechanisms of GSH in reducing hangover symptoms and improving alcohol metabolism.
About the study The clinical trial involved healthy adults aged 19 to 40, with a Body mass index (BMI) between 18.5 and 25 kg/m2, who had consumed alcohol.