STATEN ISLAND, N.Y. — Alyssa Milano , perhaps best known for her starring role as Samantha Micelli in the 1980′s ABC sitcom, “Who’s the Boss?,” and WB’s “Charmed,” will make her Broadway debut come fall in “Chicago,” that has the distinction of being named the longest-running American musical in Broadway at the Ambassador Theater.

The legendary hit musical is all set to open on Monday, Sept. 16 for an eight-week engagement through Sunday, Nov. 10.

The former Staten Islander, who once called Great Kills home, and in fact lived just a few blocks from fellow child actor Ricky Schroder, is looking with enthusiasm toward charming audiences in her new role of Roxie Hart — and adding her celebrity status to the show that was honored with six Tony Awards®, two Olivier Awards, a Grammy and thousands of standing ovations. For Milano, hitting the stage is a return to her roots. According to Advance archives, when she was 7 years-old (and living on Staten Island with her talent manager/mom Lin and her film music editor dad, Thomas), her baby-sitter took her to an audition for the musical “Annie.

” But instead of the baby-sitter getting the part, Milano would wind up landing a role as one of the orphans and was in a national touring company at age 8, according to an Associated Press story. She then went on to star in Wendy Wasserstein’s “Tender Offer” at the off-Broadway Ensemble Studio Theater and “All Night Long” at Second Stage. She was in the first .