In a recent study published in JAMA Network Open , researchers assessed associations between prescriptions of first-generation-type antihistamine drugs and seizures among children. Study: First-Generation Antihistamines and Seizures in Young Children . Image Credit: MDV Edwards/Shutterstock.
com Background Generation 1 antihistamines, initially used as tranquilizers and antipsychotics, are now used to treat common cold symptoms and decrease itchy sensations in youngsters. These drugs can pass through the blood-brain barrier (BBB). Their usage has declined due to their poor selectivity and ability to affect brain wave activity, particularly in children under two years old.
According to research, first-generation antihistamines can cause symptomatic seizures in adults while also influencing electroencephalographic activity and seizure thresholds. Generation 1 antihistamines enhance seizure susceptibility in rats, and genetically manipulated animal models support a relationship to epileptic seizures. Clinically, antihistamines have been a prevalent cause of acute symptomatic seizures, with changed seizure patterns reported in children with febrile seizures who consumed antihistamines.
However, the effect of generation 1 antihistamines on brain waves, as well as their heightened sensitivity in sensitive age groups, has gotten less attention in clinical practice. About the study In the present retrospective cohort study, researchers investigated whether the acute prescription of ge.