In a recent study published in Nature , researchers examine the role of fasting and ketogenesis in regulating protein synthesis and its potential implications for cancer therapy. Study: Remodelling of the translatome controls diet and its impact on tumorigenesis. Image Credit: Vink Fan / Shuttersotck.
com Health benefits of fasting Fasting has been historically recommended for its health benefits, with records dating back to ancient Greece. The health benefits associated with fasting can be attributed to ‘metabolic rewiring,’ during which the body utilizes ketone bodies for energy instead of glucose. This stimulates weight loss, reduces inflammation, improves brain function, and may protect against cancer.
Fasting may also support gut health by promoting a healthier and more diverse microbiome , support the regulation of key hormones including human growth hormone (HGH), leptin, and ghrelin, as well as increase longevity through its anti-aging effects. Fasting, a high-fat low-carbohydrate diet, and exercise can induce ketogenesis, which is involved in various cellular signaling pathways. Despite extensive research on the biological mechanisms that may be responsible for the health benefits of fasting, it remains unclear how this dietary approach alters the proteome.
Effects of fasting on protein translation During fasting, fatty acid levels rise due to the breakdown of fats, thereby providing an alternative source for energy production. Fasting also inhibits the mammalian .