There is a significant improvement in the cognition of children who have undergone brain surgery for epilepsy, finds a new study by UCL researchers. The study, published in Brain , retrospectively analyzed the records of 500 children who had undergone epilepsy surgery at Great Ormond Street Hospital (GOSH) between the years of 1990 and 2018. Information was extracted from IQ tests and tests of academic attainment performed many years before and after surgery.
Most children studied had shown declines in all areas of neuropsychological functioning, in comparison with their healthy peers, in the time leading up to surgery. A range of factors have been attributed as causes of cognitive impairments in children with epilepsy, including the underlying cause of their epilepsy, ongoing seizures, and use of antiseizure medication. The researchers found that children were on a downward cognitive trajectory in the years before they underwent surgery (losing on average 1–4 IQ points per year).
Based on this observation, it could be expected that, without intervention, they would have continued on this downward trajectory. However, the researchers found that the surgery not only stopped the downward trajectory of neuropsychological functioning for children who became seizure free, but also reversed it. These children continued to show improvements in cognitive functioning over the course of their long-term follow-up.
There was an additional benefit in that children were able to be weaned.