MENLO PARK, Calif. , Oct. 8, 2024 /PRNewswire/ -- Emmetrope Ophthalmics, LLC ("Emmecell"), a clinical-stage biotechnology company pioneering the discovery and development of cell-based therapies for the treatment of serious eye diseases, today announced the successful completion of the last patient last visit in its phase 1 extension study EMME-001, a 21-patient randomized, double-masked, US based, multi-center trial assessing the safety and efficacy of EO2002 for the treatment of corneal edema.
This milestone marks a significant step forward in the development of an advanced treatment option aimed at improving visual function for patients suffering from Fuchs dystrophy, pseudophakic bullous keratopathy, and other causes of corneal edema. EO2002 is a first-in-class, non-surgical cell therapy incorporating Emmecell's exclusive Magnetic Cell Delivery (MCD) nanoparticle platform. EO2002 was studied in EMME-001 as a treatment for corneal edema without the need for invasive and high-risk surgical procedures, such as corneal transplantation or endothelial scraping.
This straightforward intracameral injection is designed as a therapeutic intervention for the approximately 90% of patients with symptomatic corneal edema who do not have disease severe enough to warrant the risks of corneal transplantation surgery. Preliminary data from the phase 1 trial indicate improvement in best correct visual acuity, reduction in central corneal thickness, and no significant safety concerns, demons.