It's a question many women may ask themselves during pregnancy: Will an occasional glass of wine harm the baby? While the latest research shows the answer is definitely yes for large quantities of alcohol or , the answer is less clear for small amounts, although any carries some risk, said Vidya Rajagopalan, a principal investigator at The Saban Research Institute of Children's Hospital Los Angeles. Her research includes studying the development of a baby's brain in utero using advanced MRI scans. Rajagopalan is also participating in the National Institutes of Health's , which looks at the use of alcohol and other substances in pregnancies, she noted.

What have they found so far? Studies clearly show that drinking large quantities of alcohol while pregnant does affect a baby's health. "When pregnant women drink a lot of alcohol, they are at higher risk of having children with neuro-developmental problems," Rajagopalan said. "The science shows that occur with heavy or binge drinking.

" Such disorders involve a range of symptoms, including: Children with these disorders are more likely to have cognitive and behavioral issues, and they may also be at higher risk of developing alcohol or substance abuse problems later in their lives. But what about much smaller amounts of drinking during pregnancy? "The general guideline of national organizations like the CDC and the American College of Obstetrics and Gynecology is that there is no safe limit," Rajagopalan said. "There is no accep.