A randomized clinical trial involving obese individuals highlights the significance of dietary interventions in improving mitochondrial functions and the metabolic profile of monocytes, which are key aspects for controlling chronic inflammation in obesity. The trial report is published in the journal Clinical Nutrition . Randomized Control Trial: Intermittent fasting, calorie restriction, and a ketogenic diet improve mitochondrial function by reducing lipopolysaccharide signaling in monocytes during obesity: A randomized clinical trial .
Image Credit: Lightspring / Shutterstock Background Various dietary interventions, including calorie restriction, intermittent fasting, and ketogenic diet, have gained immense popularity for improving metabolic profiles and promoting body weight loss in obese or overweight individuals. Being the main source of cellular energy, mitochondria play a vital role in detecting and integrating environmental signals to induce adaptive cellular responses related to energy utilization. Mitochondrial dysfunction in obese individuals has been found to be associated with various chronic diseases.
Mitochondrial dysfunction in monocytes during obesity is known to contribute to low-grade chronic inflammation, a major hallmark of obesity. Recent evidence indicates that monocytes positively regulate fatty acid oxidation to reduce inflammatory responses in low-glucose environments. This suggests that dietary restrictions may influence monocyte bioenergetics.
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