In a recent study published in the journal BMJ , researchers conducted a registry-based study comprising 343,066 infants across Denmark, Sweden, and Norway to investigate if COVID-19 infections or vaccinations during the first trimester were associated with increased risk of congenital anomalies. Of the 11 anomaly subgroups investigated, 10 had adjusted odds ratios (aORs) < 1.04 highlighting no statistically significant risk increases.
Study: Covid-19 infection and vaccination during first trimester and risk of congenital anomalies: Nordic registry based study . Image Credit: Unai Huizi Photography / Shutterstock Background Pregnant women represent a high-risk population, with disease contractions during pregnancy often adversely affecting pregnancy and birth outcomes. Observational accounts and recent research have revealed that Coronavirus disease 2019 (COVID-19) infections during pregnancy comply with this trend, increasing the risk of severe illness and pregnancy complications.
Given this knowledge, governments of most nations recommend that pregnant women receive COVID-19 vaccinations. The first trimester represents a critical period of pregnancy, with most congenital anomalies developing during these first three months. Unfortunately, pregnant women are rarely subjected to randomized controlled trials, preventing robust scientific evidence for the safety of vaccinations in this high-risk group.
Encouragingly, observational evidence and registry-based studies conducted a.