Since revealing she was diagnosed with multiple sclerosis (MS) in 2021, Christina Applegate has been candid about her health and how's she's doing. She recently passed the three-year anniversary of receiving her diagnosis, and opened up about the day she received the news in an August 2024 episode “ ." “They did an MRI in my brain, and it was a Monday, and we were at work.

And my doctor said, ‘I really need to get on a Zoom with you to go over your MRI results,'" she recalled. “And I opened up my Zoom and there he was, and he just looked at me and he goes, ‘I’m so sorry.’ And I was like, ‘What do you mean?’ And he goes, ‘Here’s a picture of your brain, sorry.

’ And there’s like 30 lesions all over my brain. And I went, ‘No, please don’t tell me this. Please don’t.

’” Applegate still struggles to accept her diagnosis, she shared in which she co-hosts with actor Jamie-Lynn Sigler. "I’m still sitting here like, ‘Boohoo, woe is me.’ I’m still mad about it," she told Sigler, who for over 20 years.

The "Dead To Me" star initially in August 2021. MS is a “potentially disabling disease of the brain and spinal cord,” . MS can create “communication problems between your brain and the rest of your body” and “permanent damage or deterioration of the nerve fibers.

” Read on for a full timeline of what Applegate has said about having MS. On the third episode of MeSsy, Applegate revealed she was in a relapse that the time of the recording.